CV

Contents

Present Position

Research Associate Professor of Psychiatry

Washington University School of MedicineSaint Louis, Missouri

Education


Undergraduate

Rensselaer Polytechnic Institute, Troy, New York: 1987-1990. B.A. in Mathematics, graduated with honors and received Max Hirsch Prize in Mathematics.


Graduate

Brown University, Providence, Rhode Island: 1990-1995. Ph.D. in Pure Mathematics. Thesis Adviser: Dr. Brian Cole.

Thesis Title: A Study of Strongly Tight Uniform Algebras

Academic Positions

2013 –Research Associate Professor of Psychiatry, Washington University
St. Louis, Missouri

2007 – 2013

Research Assistant Professor of Psychiatry, Washington University
St. Louis, Missouri

2005 – 2007

Research Instructor in Psychiatry, Washington University
St. Louis, Missouri

2002 – 2005

Postdoctoral Trainee in Psychiatry, Washington University
St. Louis, Missouri

2000 – 2002

Assistant Professor of Mathematics, Saint Louis University
St. Louis, Missouri

1999 – 2000

Visiting Assistant Professor of Mathematics, Saint Louis University
St. Louis, Missouri

1998 – 1999

Visiting Assistant Professor of Mathematics, The University of Missouri at Columbia
Columbia, Missouri

1996 – 1998

Visiting Assistant Professor of Mathematics, Washington University
St. Louis, Missouri

1995 – 1995

Visiting Assistant Professor of Mathematics, Northwestern University
Evanston, Illinois

May 1995

Visitor, Mathematical Sciences Research Institute, The University of California
Berkeley, California

Editorial Responsibilities

Served as referee

  • The American Journal of Psychiatry
  • Annals of Human Genetics
  • Biological Psychiatry
  • Bioinformatics
  • BMC Medical Genetics
  • Database
  • Genetics
  • Genome Biology
  • Human Heredity
  • The Journal of Functional Analysis
  • Molecular Psychiatry
  • Nucleic Acids Research
  • PLoS One
  • Proceedings of the American Mathematical Society

Other Appointments and Committees

2009 –

Advisory Board, Genes, Environment and Development Initiative (GEDI)

2009 – 2010

Human Research Protection Office, Washington University, New Protocols Committee #03

2007 – 2008

Advisory Board, Pharmacogenetics of Nicotine Addiction Treatment (PNAT)

Present Research Support

National Institute On Drug Abuse, 5K01DA024722-02
Role Principal Investigator
Title Design and Interpretation of SNP Association Studies of Addiction
Duration 04/01/09 – 08/31/14
Primary Mentor Dr. John Rice

Past Research Support

American Cancer Society, IRG 58-010-50
Role Principal Investigator
Title Identifying Genetic Risk Loci for Nicotine Dependence
Duration 11/1/06-10/31/07

National Institute of Mental Health, 1U24MH68457-01
Role Co-Investigator
Title NIMH Center for Collaborative Genetic Studies
Duration07/01/03-05/31/13
Principal Investigator Dr. Jay Tischfield

National Institute on Drug Abuse, Contract 271200900012C-0-0-1
Role Co-investigator
Title NIDA Center for Genetic Studies
Duration 09/30/99 - 04/30/12
Principal Investigator Dr. Jay Tischfield

National Institute On Drug Abuse, R01DA012854
Role Co-Investigator
Title The Genetics Of Vulnerability To Nicotine Addictions
Duration 5/25/00-4/30/13
Principal Investigator Dr. Pamela Madden

National Cancer Institute, P01CA89392-01
Role Co-Investigator
Title The Collaborative Genetic Study of Nicotine Dependence
Duration 12/01/00-06/30/13
Principal Investigator Dr. Laura Bierut

National Institute on Alcohol Abuse and Alcoholism, T32AA07580
Role Trainee
Title Biomedical Training in Alcoholism Research
Duration 7/1/02-5/31/05
Principal Investigator Dr. Andrew Heath
Mentor Dr. John Rice

National Science Foundation, #9705851
Role Principal Investigator
Title Hankel-Type Operators on Banach Spaces of Analytic Functions
Duration 8/1/1997 – 7/31/2000

Invited Lectureships

  • "Using public genomic databases to study the genetics of human disease" in A short course on the genetics of addiction, The Jackson Laboratory, August 2011.
  • "Using bioinformatics to prioritize genetic variants for addiction" in A Short Course on the Genetics and Epigenetics of Addiction, The National Institute on Drug Abuse, April 2008.

Bibliography

Peer-reviewed publications

  1. Saccone SF, Quan J,  Jones JP.  BioQ: tracing experimental origins in public genomic databases using a novel data provenance model. Bioinformatics 2012,. 28(8), 1189-1191.
  2. Rice J.P., Hartz S., Agrawal A., Almasy L., Bennett S., Breslau N., Bucholz K.K., Doheny K.F., Edenberg H.J., Goate A.M., Hesselbrock V., Howells W.B., Johnson E.O., Kramer J., Krueger R.F., Kuperman S., Laurie C., Manolio T.A., Neuman R.J., Nurnberger J.I., Porjesz B., Pugh E., Ramos E.M., Saccone N., Saccone S., Schuckit M., Bierut L.J. CHRNB3 is more strongly associated with FTCD-based nicotine dependence than cigarettes per day: phenotype definition changes GWAS results. Addiction. 2012. 107(11), 2019-2028
  3. Keskitalo-Vuokko K., Hallfors J., Broms U., Pergadia M.L., Saccone S.F., Loukola A., Madden P.A., Kaprio J. Chromosome 20 shows linkage with DSM-IV nicotine dependence in finnish adult smokers. Nicotine Tob Res 2012. 14(2), 153-160
  4. Derringer J., Krueger R.F., Dick D.M., Aliev F., Grucza R.A., Saccone S.F., Agrawal A., Edenberg H.J., Goate A.M., Hesselbrock V.M., Kramer J.R., Lin P., Neuman R.J., Nurnberger J.I., Jr., Rice J.P., Tischfield J.A., Bierut L.J. (2012). The Aggregate Effect of Dopamine Genes on Dependence Symptoms Among Cocaine Users: Cross-Validation of a Candidate System Scoring Approach. Behav Genet. 2012. 42(4), 626-635
  5. Chen L.S., Baker T.B., Grucza R., Wang J.C., Johnson E.O., Breslau N., Hatsukami D., Smith S.S., Saccone N., Saccone S., Rice J.P., Goate A.M., Bierut L.J. Dissection of the phenotypic and genotypic associations with nicotinic dependence. Nicotine Tob Res 2012. 14(4), 425-433
  6. Huang Y.H., Rice J.P., Saccone S.F., Ambite J.L., Arens Y., Tischfield J.A., Hsu C.N. (2012). A nu-support vector regression based approach for predicting imputation quality. BMC proceedings 6 Suppl 7, S3. 
  7. Saccone SF, Quan J, Mehta G, Bolze R, Thomas P, Deelman E, Tischfield JA, Rice JP: New tools and methods for direct programmatic access to the dbSNP relational database. Nucleic Acids Res 2011; 39 Suppl: D901-D907
  8. Agrawal A, Lynskey MT, Hinrichs A, Grucza R, Saccone SF, Krueger R, Neuman R, Howells W, Fisher S, Fox L, Cloninger R, Dick DM, Doheny KF, Edenberg HJ, Goate AM, Hesselbrock V, Johnson E, Kramer J, Kuperman S, Nurnberger Jr JI, Pugh E, Schuckit M, Tischfield J; The GENEVA Consortium, Rice JP, Bucholz KK, Bierut LJ (2011). A genome-wide association study of DSM-IV cannabis dependence. Addict Biol. 2011 Jul;16(3):514-518
  9. Pergadia M.L., Glowinski A.L., Wray N.R., Agrawal A., Saccone S.F., Loukola A., Broms U., Korhonen T., Penninx B.W., Grant J.D., Nelson E.C., Henders A.K., Schrage A.J., Chou Y.L., Keskitalo-Vuokko K., Zhu Q., Gordon S.D., Vink J.M., de Geus E.J., Macgregor S., Liu J.Z., Willemsen G., Medland S.E., Boomsma D.I., Montgomery G.W., Rice J.P., Goate A.M., Heath A.C., Kaprio J., Martin N.G., Madden P.A. (2011). A 3p26-3p25 Genetic Linkage Finding for DSM-IV Major Depression in Heavy Smoking Families. American Journal of Psychiatry (in press)
  10. Hinrichs A.L., Murphy S.E., Wang J.C., Saccone S., Saccone N., Steinbach J.H., Goate A., Stevens V.L., Bierut L.J. (2011). Common polymorphisms in FMO1 are associated with nicotine dependence. Pharmacogenet Genomics (in press)
  11. Saccone SF, Bolze R, Thomas P, Quan J, Mehta G, Deelman E, Tischfield JA, Rice JP: SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study. Nucleic Acids Res 2010; 38 Suppl*:* W201-209.
  12. McEachin RC , Chen H , Sartor MA, Saccone SF, Keller BF, Prossin AR, Cavalcoli JD, McInnis MG: A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder, BMC Systems Biology_, In Press_
  13. Knight J, Rochberg N,. Saccone SF, Nurnberger J, Rice JP and NIMH Genetics Initiative Bipolar Disorder Consortium: Investigation of Candidate Regions for Association With Bipolar Disorder. American Journal of Medical Genetics - Neuropsychiatric Genetics; In Press
  14. Derringer J, Krueger RF, Dick DM, Saccone S, Grucza RA, Agrawal A, Lin P, Almasy L, Edenberg HJ, Foroud T, Nurnberger JI, Jr., Hesselbrock VM, Kramer JR, Kuperman S, Porjesz B, Schuckit MA, Bierut LJ: Predicting Sensation Seeking From Dopamine Genes: A Candidate-System Approach. Psychol Sci; In Press
  15. Hartz S, Lin P, Edenberg HJ, Xueij X, Rochberg N, Saccone S, Berrettini W, Elliot Nelson E, Nurnberger J, Bierut L Rice J, NIMH Genetics Initiative Bipolar Disorder Consortium: Genetic association of bipolar disorder with the b3 nicotinic receptor subunit gene. In Press
  16. Bierut LJ, Agrawal A, Bucholz KK, Doheny KF, Laurie C, Pugh E, Fisher S, Fox L, Howells W, Bertelsen S, Hinrichs AL, Almasy L, Breslau N, Culverhouse RC, Dick DM, Edenberg HJ, Foroud T, Grucza RA, Hatsukami D, Hesselbrock V, Johnson EO, Kramer J, Krueger RF, Kuperman S, Lynskey M, Mann K, Neuman RJ, Nöthen MM, Nurnberger JI, Porjesz B, Ridinger M, Saccone NL, Saccone SF, Schuckit MA, Tischfield JA, Wang JC, Rietschel M, Goate AM, Rice JP: A genome-wide association study of alcohol dependence. Proc Natl Acad Sci 2010; 107: 5082-5087
  17. Lin P, Hartz SM, Zhang Z, Saccone SF, Wang J, Tischfield JA, Edenberg HJ, Kramer JR, A MG, Bierut LJ, Rice JP: A new statistic to evaluate imputation reliability. PLoS ONE 2010; 5*:* e9697
  18. McEachin RC, Saccone NL, Saccone SF, Kleyman-Smith YD, Kar T, Kare RK, Ade AS, Sartor MA, Cavalcoli JD, McInnis MG: Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder. BMC Med Genet 2010; 11*:* 14
  19. Nelson EC, Agrawal A, Pergadia ML, Wang JC, Whitfield JB, Saccone FS, Kern J, Grant JD, Schrage AJ, Rice JP, Montgomery GW, Heath AC, Goate AM, Martin NG, Madden PA: H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. Addict Biol 2010; 15: 1-11
  20. Saccone SF, Bierut LJ, Chesler EJ, Kalivas PW, Lerman C, Saccone NL, Uhl GR, Li CY, Philip VM, Edenberg HJ, Sherry ST, Feolo M, Moyzis RK, Rutter JL: Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm. PLoS ONE 2009, 4: e5225
  21. Wang JC, Cruchaga C, Saccone NL, Bertelsen S, Liu P, Budde JP, Duan W, Fox L, Grucza RA, Kern J, Mayo K, Reyes O, Rice J, Saccone SF, Spiegel N, Steinbach JH, Stitzel JA, Anderson MW, You M, Stevens VL, Bierut LJ, Goate AM: Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Hum Mol Genet 2009; 18: 125-3135
  22. Wang JC, Grucza R, Cruchaga C, Hinrichs AL, Bertelsen S, Budde JP, Fox L, Goldstein E, Reyes O, Saccone N, Saccone S, Xuei X, Bucholz K, Kuperman S, Nurnberger J, Jr., Rice JP, Schuckit M, Tischfield J, Hesselbrock V, Porjesz B, Edenberg HJ, Bierut LJ, Goate AM: Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Mol Psychiatry 2009; 14: 501-510
  23. Saccone NL, Wang JC, Breslau N, Johnson EO, Hatsukami D, Saccone SF, Grucza RA, Sun L, Duan W, Budde J, Culverhouse RC, Fox L, Hinrichs AL, Steinbach JH, Wu M, Rice JP, Goate AM, Bierut LJ: The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res 2009; 69*:* 6848-6856
  24. Pergadia ML, Agrawal A, Loukola A, Montgomery GW, Broms U, Saccone SF, Wang JC, Todorov AA, Heikkilä K, Statham DJ, Henders AK, Campbell MJ, Rice JP, Todd RD, Heath AC, Goate AM, Peltonen L, Kaprio J, Martin NG, Madden PA: Genetic linkage findings for DSM-IV nicotine withdrawal in two populations. Am J Med Genet B Neuropsychiatr Genet. 2009; 150B: 950-959
  25. Agrawal A, Pergadia ML, Balasubramanian S, Saccone SF, Hinrichs AL, Saccone NL, Breslau N, Johnson EO, Hatsukami D, Martin NG, Montgomery GW, Goate AM, Rice JP, Bierut LJ, Madden PA: Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence. Addiction 2009; 104:471-7
  26. Saccone NL, Saccone SF , Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A, Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PAF, Swan GE, Wang JC, Goate AM, Rice JP, Bierut LJ: Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am. J. Med. Genet. B Neuropsychiatr Genet 2009_;_ 150B:453-466
  27. Knight J, Saccone SF, Zhang Z, Ballinger D, Rice JP: A comparison of association statistics between pooled and individual genotypes. Human Heredity 2009_;_ 67:219-225
  28. Wang JC, Grucza R, Cruchaga C, Hinrichs AL, Bertelsen S, Budde JP, Fox L, Goldstein E, Reyes O, Saccone N, Saccone S, Xuei X, Bucholz K, Kuperman S, Nurnberger J Jr, Rice JP, Schuckit M, Tischfield J, Hesselbrock V, Porjesz B, Edenberg HJ, Bierut LJ, Goate AM: Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence, Molecular Psychiatry 2009; 14: 501-510
  29. Saccone NL, Saccone SF, Goate AM, Grucza RA, Hinrichs AL, Rice JP, Bierut LJ: In search of causal variants: refining disease association signals using cross-population contrasts. BMC Genet 2008, 9:58
  30. Saccone SF, Saccone NL, Swan GE, Madden PAF, Goate AM, Rice JP, Bierut LJ: Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence, Bioinformatics 2008; 24, 1805-1811.
  31. Agrawal A, Pergadia ML, Saccone SF, Lynskey MT, Wang JC, Martin NG, Statham D, MPsychClin, Henders A, Campbell M, Garcia R, Broms U, Todd RD, Goate AM, Rice JP, Kaprio J, Heath AC, Montgomery GW, Madden PAF: An Autosomal Linkage Scan for Cannabis Use Disorders in the Nicotine Addiction Genetics Project. Archives of General Psychiatry 2008; 65:713-21
  32. Liu Y, Helms C, Liao W, Zaba LC, Duan S, Gardner J, Wise C, Miner A, Malloy MJ, Pullinger C, Kane J, Saccone S, Worthington J, Bruce I, Kwok P-Y, Menter A, Krueger J, Barton A, Saccone NL, Bowcock AM. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genetics 2008; 4*:*e1000041
  33. Bierut, L.J., Stitzel, J.A., Wang, J.C., Hinrichs, A.L., Grucza, R.A., Xuei, X., Saccone, N.L., Saccone, S.F., Bertelsen, S., Fox, L., Horton, W.J., Breslau, N., Budde, J., Cloninger, C.R., Dick, D.M., Foroud, T., Hatsukami, D., Hesselbrock, V., Johnson, E.O., Kramer, J., Kuperman, S., Madden, P.A., Mayo, K., Nurnberger, J., Pomerleau, O., Porjesz, B., Reyes, O., Schuckit, M., Swan, G., Tischfield, J.A., Edenberg, H.J., Rice, J.P. and Goate, A.M.: Variants in Nicotinic Receptors and Risk for Nicotine Dependence, Am J Psychiatry. 2008; 165:1163-71
  34. Grucza, R.A., Wang, J.C., Stitzel, J.A., Hinrichs, A.L., Saccone, S.F., Saccone, N.L., Bucholz, K.K., Cloninger, C.R., Neuman, R.J., Budde, J.P., Fox, L., Bertelsen, S., Kramer, J., Hesselbrock, V., Tischfield, J., Nurnberger, J.I., Almasy, L., Porjesz, B., Kuperman, S., Schuckit, M.A., Edenberg, H.J., Rice, J.P., Goate, A.M. and Bierut, L.J.: A Risk Allele for Nicotine Dependence in CHRNA5 Is a Protective Allele for Cocaine Dependence, Biol Psychiatry 2008, 64:922-9
  35. Saccone NL, Saccone SF, Goate AM, Grucza RA, Hinrichs AL, Rice JP, Bierut LJ: In search of causal variants: refining disease association signals using cross-population contrasts. BMC Genet 2008; 9.
  36. Saccone SF, Pergadia ML, Loukola A, Broms Ulla, Montgomery GW, Wang JC, Agrawal A, Dick DM, Heath AC, Todorov AA, Maunu H, Heikkilä K, Morley KI, Rice JP, Todd RD, Kaprio J, Peltonen L, Martin NG, Goate AM, Madden PAF: Genetic Linkage to Chromosome 22q12 for a Heavy Smoking Quantitative Trait in Two Independent Samples. The American Journal of Human Genetics 2007; 80: 856-866
  37. Dick D, Aliev F, Wang JC, Saccone SF, Hinrichs A, Bertelsen S, Budde J, Saccone N, Foroud T, Nurnberger J, Xuei X, Conneally PM, Schuckit M, Almasy L, Crowe R, Kuperman S, Kramer J, Tischfield JA, Hesselbrock V, Edenberg HJ, Porjesz B, Rice JP, Bierut LJ, Goate AM: A Systematic Single Nucleotide Polymorphism Screen to Fine-Map Alcohol Dependence Genes on Chromosome 7 Identifies Association with a Novel Susceptibility Gene ACN9, Biological Psychiatry 2008; 63: 1047-1053
  38. Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Karel Konvicka, Madden PAF, Breslau N, Johnson E, Hatsukami D, Pomerleau O, Swan GE, Goate AM, Rutter J, Bertelsen S, Fox L, Fugman D, Martin NG, Montgomery GW, Wang JC, Ballinger DG, Rice JP, Bierut LJ: Cholinergic Nicotinic Receptor Genes Implicated in a Nicotine Dependence Association Study Targeting 348 Candidate Genes with 3,713 SNPs. Human Molecular Genetics 2007; 16: 36-49
  39. Bierut LJ, Madden PAF, Breslau N, Johnson EO, Hatsukami D, Pomerleau OF, Swan GE, Rutter J, Bertelsen S, Fox L, Fugman D, Goate AM, Hinrichs AL, Konvicka K, Martin N, Montgomery G, Saccone NL, Saccone SF, Wang JC, Chase GA, Rice JP, Ballinger DG. Novel Genes Identified in a High Density Genome Wide Association Study for Nicotine Dependence. Human Molecular Genetics 2007; 16*:*24-35
  40. Saccone SF, Rice JP, Saccone NL: Power-based, phase-informed selection of single nucleotide polymorphisms for disease association screens. Genetic Epidemiology 2006; 30: 459-470
  41. Saccone SF, Saccone NL, Neuman RJ, Rice JP: Genetic analysis of the maximum number of drinks phenotype. BMC Genetics 2005; 6: Supplement 1, S124
  42. Rice JP, Saccone SF: Alcoholism and related traits: a summary of Group 13 contributions. Genetic Epidemiology 2005; 29: Supplement 1, S96-S102
  43. Taillon-Miller P*, Saccone SF, Saccone NL, Duan , EF Kloss, Lovins EG, Donaldson R, Phong A, Ha C, Flagstad L, Miller S, Drendel A, Lind D, Miller RD, Rice JP, Kwok P-Y: Linkage disequilibrium maps constructed with common SNPs are useful for first-pass disease association screens. Genomics 2004, 84: 899-912 *Equal first authors
  44. Saccone NL, Neuman RJ, Saccone SF, Rice JP: Genetic analysis of maximum cigarette-use phenotypes. Genetic Analysis Workshop 13: Analysis of Tobacco and Alcohol Phenotypes, BMC Genetics 2003; 4: Supplement 1, S105
  45. Saccone SF: Function theory in spaces of uniformly convergent Fourier series. Proceedings of the American Mathematical Society 2000; 128: 1813-1823
  46. Saccone SF: The Pelczynski property for tight subspaces. Journal of Functional Analysis 1997; 148: 86-116
  47. Saccone SF: Banach space properties of tight uniform algebras. Studia Mathematica 1995; 114: 159-180
  48. Saccone SF: Tight uniform algebras. Proceedings of the Workshop on Holomorphic Spaces at the Mathematical Sciences Research Institute 1995: 135-154

Peer-reviewed technology

Web tool and database resource: BioQ, http://bioq.saclab.net
Associated PublicationSaccone SF, Quan J,  Jones JP.  BioQ: tracing experimental origins in public genomic databases using a novel data provenance model. Bioinformatics 2012,. 28(8), 1189-1191.

Web tool and database resource: dbSNP-Q, https://cgsmd.isi.edu/dbsnpq.
Associated PublicationSaccone SF, Quan J, Mehta G, Bolze R, Thomas P, Deelman E, Tischfield JA, Rice JP. (2010). New tools and methods for direct programmatic access to the dbSNP relational database. . Nucleic Acids Res 2011; 39 Suppl: D901-D907

Web tool: SPOT - the SNP Prioritization Online Tool, https://spot.cgsmd.isi.edu.
Associated PublicationSaccone SF, Bolze R, Thomas P, Quan J, Mehta G, Deelman E, Tischfield JA, Rice JP: SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study. Nucleic Acids Res 2010; 38 Suppl*:* W201-209

Online database: The NeuroSNP Project, http://zork.wustl.edu/nida/neurosnp/index.htm.
Associated PublicationSaccone SF, Bierut LJ, Chesler EJ, Kalivas PW, Lerman C, Saccone NL, Uhl GR, Li CY, Philip VM, Edenberg HJ, Sherry ST, Feolo M, Moyzis RK, Rutter JL: Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm. PLoS ONE 2009; 4: e5225

Book Chapters

  1. Saccone SF, Applying In Silico Integrative Genomics to Genetics Studies of Human Disease: A Review, In E.J. Chesler and M. Haendel (Eds.) Bioinformatics of Behavior, International Review of Neurobiology, 2012, 103.